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If you are taking this medication to prevent attacks of pain caused by familial Mediterranean feverthe usual dose is 1.2 to 2.4 milligrams dailyThe total dose may be taken once daily or divided into two doses a dayYour doctor may need to adjust your dose to control your symptoms or if you have side effects.

The first stage of acute colchicine toxicity typically begins within 24 hours of ingestion and includes gastrointestinal symptoms such as abdominal painnauseavomitingdiarrheaand significant fluid lossleading to volume depletionPeripheral leukocytosis may also be seenLife-threatening complications occur during the second stagewhich occurs 24 to 72 hours after drug administrationattributed to multi-organ failure and its associated consequencesDeath usually results from respiratory depression and cardiovascular collapseIf the patient survivesrecovery of multi-organ injury may be accompanied by rebound leukocytosis and alopecia starting buying_viagra_in_canada, buying_viagra_in_canada, buying_viagra_in_canada, buying_viagra_in_canada, buying_viagra_in_canada, buying_viagra_in_canada. about 1 week after the initial ingestionTreatment of colchicine overdose should begin with gastric lavage and measures to prevent shockOtherwisetreatment is symptomatic and supportiveNo specific antidote is knownColchicine is not effectively removed by hemodialysisSee Pharmacokinetics

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colchicine binds to proteins in the microtubules of neutrophils.


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