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15Crane MGHarris JJWinsor W 3dHypertensionoral contraceptive agentsand conjugated estrogensAnn Intern Med 74197113-21.

The distribution of exogenous estrogens is similar to that of endogenous estrogensEstrogens are widely distributed in the body and are generally found in higher concentrations in the sex hormone target organsEstrogens circulate in the blood largely bound to sex hormone binding globulinSHBGand albumin.

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Postmarketing reportsVaginal irritationvaginal paingenital prurituschanges in bleeding patternpelvic painbreast tendernessvaginal ulcerationuterine fibroidsRef]

Because estrogens Here,,,,,,,,,,,,, here, here, here, here, here, here, here, here, here, here, here. may cause some degree of fluid retentionpatients with conditions that might be influenced by this factorsuch as asthmaepilepsymigraineand cardiac or renal dysfunctionwarrant careful observation when estrogens are prescribed.

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you should avoid using estrace if you are pregnant, if you have unusual vaginal bleeding, liver problems, breast or uterine cancer, hormone-dependent cancer, if you have recently had heart attack or stroke, if you have a history of blood clot especially in your lung or your lower body , or if you have allergy to any medicines or food dyes.


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